Colonel John Grymes was the son of John and Alice Grymes. He married Lucy Ludwell and was the father of Hannah and Lucy Grymes, Phillip Grymes, John Grymes, Charles Grymes, Alice Grymes, and Benjamin and Ludwell Grymes. He built Brandon Plantation in Middlesex County. The artist is unknown, but may be Charles Bridges who painted a number of his children.
The portrait features a man seated at a cloth-covered table or desk in a chair. His right arm rests on the table and holds a piece of paper. His left hand is tucked into his waistcoat. There is a bookshelf filled with books behind him on the left side of the canvas.
Special thanks to Richmond Conservation Studios for information about this portrait.